2023 / 2022 / 2021 / 2020

2023

  • Hosang L, Löhndorf A, Dohle W, Rosche A, Marry S, Diercks BP, Müller-Kirschbaum LC, Flügel LT, Potter BVL, Odoardi F, Guse AH, Flügel A. 2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca2+ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.. Biochim Biophys Acta Mol Cell Res. 2023 May 6;1870(6):119485. doi: 10.1016/j.bbamcr.2023.119485. Epub ahead of print. PMID: 37150482. (Pubmed)
     
  • Biljecki M, Eisenhut K, Beltrán E, Winklmeier S, Mader S, Thaller A, Eichhorn P, Steininger P, Flierl-Hecht A, Lewerenz J, Kümpfel T, Kerschensteiner M, Meinl E, Thaler FS. Antibodies Against Glutamic Acid Decarboxylase 65 Are Locally Produced in the CSF and Arise During Affinity Maturation. Neurol Neuroimmunol Neuroinflamm. 2023 Feb 23;10(3):e200090. doi: 10.1212/NXI.0000000000200090. PMID: 36823135; PMCID: PMC9969496. (Pubmed)
     
  • Arinrad S, Wilke JBH, Seelbach A, Doeren J, Hindermann M, Butt UJ, Steixner-Kumar AA, Spieth L, Ronnenberg A, Pan H, Berghoff SA, Hollmann M, Lühder F, Nave KA, Bechter K, Ehrenreich H. NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with neuropsychiatric relevance. Mol Psychiatry. 2022 Dec;27(12):4974-4983. doi: 10.1038/s41380-021-01392-8. Epub 2021 Dec 6. PMID: 34866134; PMCID: PMC9763107. (Pubmed)
     
  • Mezydlo A, Treiber N, Ullrich Gavilanes EM, Eichenseer K, Ancău M, Wens A, Ares Carral C, Schifferer M, Snaidero N, Misgeld T, Kerschensteiner M. Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex.. Neuron. 2023 Apr 17:S0896-6273(23)00227-1. doi: 10.1016/j.neuron.2023.03.031. Epub ahead of print. PMID: 37071991. (Pubmed)
     
  • Petrucco L, Lavian H, Wu YK, Svara F, Štih V, Portugues R. Neural dynamics and architecture of the heading direction circuit in zebrafish.. Nat Neurosci. 2023 May;26(5):765-773. doi: 10.1038/s41593-023-01308-5. Epub 2023 Apr 24. PMID: 37095397; PMCID: PMC10166860. (Pubmed)
     
  • Aljović A, Jacobi A, Marcantoni M, Kagerer F, Loy K, Kendirli A, Bräutigam J, Fabbio L, Van Steenbergen V, Pleśniar K, Kerschensteiner M, Bareyre FM. Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury. EMBO Mol Med. 2023 Feb 8;15(2):e16111. doi: 10.15252/emmm.202216111. Epub 2023 Jan 5. PMID: 36601738; PMCID: PMC9906383. (Pubmed)
     
  • Schlotawa L, Tyka K, Kettwig M, Ahrens-Nicklas RC, Baud M, Berulava T, Brunetti-Pierri N, Gagne A, Herbst ZM, Maguire JA, Monfregola J, Pena T, Radhakrishnan K, Schröder S, Waxman EA, Ballabio A, Dierks T, Fischer A, French DL, Gelb MH, Gärtner J. Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency. EMBO Mol Med. 2023 Mar 8;15(3):e14837. doi: 10.15252/emmm.202114837. Epub 2023 Feb 15. PMID: 36789546; PMCID: PMC9994482. (Pubmed)
     
  • Dybowski S, Torke S, Weber MS. Targeting B Cells and Microglia in Multiple Sclerosis With Bruton Tyrosine Kinase Inhibitors: A Review. JAMA Neurol. 2023 Apr 1;80(4):404-414. doi: 10.1001/jamaneurol.2022.5332. PMID: 36780171. (Pubmed)
     
  • Dawkins E, Derks RJE, Schifferer M, Trambauer J, Winkler E, Simons M, Paquet D, Giera M, Kamp F, Steiner H. Membrane lipid remodeling modulates γ-secretase processivity. J Biol Chem. 2023 Feb 16;299(4):103027. doi: 10.1016/j.jbc.2023.103027. Epub ahead of print. PMID: 36805335; PMCID: PMC10070668. (Pubmed)
     
  • Hannelore Ehrenreich MD, DVM, Max Gassmann DVM, Luise Poustka MD, Martin Burtscher MD, Peter Hammermann PhD, Anna-Leena Sirén MD, PhD, Klaus-Armin Nave PhD, Kamilla Miskowiak PhD. Exploiting moderate hypoxia to benefit patients with brain disease: Molecular mechanisms and translational research in progress. (Link)
     
  • Djannatian M, Radha S, Weikert U, Safaiyan S, Wrede C, Deichsel C, Kislinger G, Rhomberg A, Ruhwedel T, Campbell DS, van Ham T, Schmid B, Hegermann J, Möbius W, Schifferer M, Simons M. Myelination generates aberrant ultrastructure that is resolved by microglia. J Cell Biol. 2023 Mar 6;222(3):e202204010. doi: 10.1083/jcb.202204010. Epub 2023 Jan 13. PMID: 36637807; PMCID: PMC9856851. (Pubmed)

2022

  • Cantuti-Castelvetri L, Gokce O, Simons M. Reparative inflammation in multiple sclerosis. Semin Immunol. 2022 Jan;59:101630. doi: 10.1016/j.smim.2022.101630. Epub 2022 Jun 22. PMID: 35750551. (Pubmed)
     
  • Hersbach BA, Fischer DS, Masserdotti G, Deeksha, Mojžišová K, Waltzhöni T, Rodriguez-Terrones D, Heinig M, Theis FJ, Götz M, Stricker SH. Probing cell identity hierarchies by fate titration and collision during direct reprogramming. Mol Syst Biol. 2022 Sep;18(9):e11129. doi: 10.15252/msb.202211129. PMID: 36106915; PMCID: PMC9476893. (Pubmed)
     
  • Ehrenreich H. For decades against the mainstream - From erythropoietin and hypoxia as novel treatment strategies to deep phenotyping in neuropsychiatric disorders. Psychiatry Res. 2022 Nov;317:114854. doi: 10.1016/j.psychres.2022.114854. Epub 2022 Sep 17. PMID: 36170796; PMCID: PMC7613706. (Pubmed)
     
  • Aly L, Noll C, Wicklein R, Wolf E, Romahn EF, Wauschkuhn J, Hosari S, Mardin C, Berthele A, Hemmer B, Korn T, Knier B. Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2022 Mar 17;9(3):e1159. doi: 10.1212/NXI.0000000000001159. PMID: 35301260; PMCID: PMC8931743. (Pubmed)
     
  • Liu T, Stephan T, Chen P, Keller-Findeisen J, Chen J, Riedel D, Yang Z, Jakobs S, Chen Z. Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain. Proc Natl Acad Sci U S A. 2022 Dec 27;119(52):e2215799119. doi: 10.1073/pnas.2215799119. Epub 2022 Dec 19. PMID: 36534799; PMCID: PMC9907107. (Pubmed)
     
  • Mitsdoerffer M, Aly L, Barz M, Engleitner T, Sie C, Delbridge C, Lepennetier G, Öllinger R, Pfaller M, Wiestler B, Rad R, Meyer B, Knier B, Schmidt-Graf F, Gempt J, Korn T. The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the TH17 lineage in humans. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2206208119. doi: 10.1073/pnas.2206208119. Epub 2022 Aug 15. PMID: 35969754; PMCID: PMC9407554. (Pubmed)
     
  • Ehrenreich H, Garcia-Agudo LF, Steixner-Kumar AA, Wilke JBH, Butt UJ. Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance. Mol Psychiatry. 2022 May;27(5):2372-2379. doi: 10.1038/s41380-022-01551-5. Epub 2022 Apr 12. PMID: 35414656; PMCID: PMC9004453. (Pubmed)
     
  • Thomas J, Martinez-Reza MF, Thorwirth M, Zarb Y, Conzelmann KK, Hauck SM, Grade S, Götz M. Excessive local host-graft connectivity in aging and amyloid-loaded brain. Sci Adv. 2022 Jun 10;8(23):eabg9287. doi: 10.1126/sciadv.abg9287. Epub 2022 Jun 10. PMID: 35687689; PMCID: PMC9187230. (Pubmed)
     
  • Düking T, Spieth L, Berghoff SA, Piepkorn L, Schmidke AM, Mitkovski M, Kannaiyan N, Hosang L, Scholz P, Shaib AH, Schneider LV, Hesse D, Ruhwedel T, Sun T, Linhoff L, Trevisiol A, Köhler S, Pastor AM, Misgeld T, Sereda M, Hassouna I, Rossner MJ, Odoardi F, Ischebeck T, de Hoz L, Hirrlinger J, Jahn O, Saher G. Ketogenic diet uncovers differential metabolic plasticity of brain cells. Sci Adv. 2022 Sep 16;8(37):eabo7639. doi: 10.1126/sciadv.abo7639. Epub 2022 Sep 16. PMID: 36112685; PMCID: PMC9481126. (Pubmed)
     
  • Grade S, Thomas J, Zarb Y, Thorwirth M, Conzelmann KK, Hauck SM, Götz M. Brain injury environment critically influences the connectivity of transplanted neurons. Sci Adv. 2022 Jun 10;8(23):eabg9445. doi: 10.1126/sciadv.abg9445. Epub 2022 Jun 10. PMID: 35687687; PMCID: PMC9187233. (Pubmed)
     
  • Khalin I, Adarsh N, Schifferer M, Wehn A, Groschup B, Misgeld T, Klymchenko A, Plesnila N. Size-Selective Transfer of Lipid Nanoparticle-Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury. Small. 2022 May;18(18):e2200302. doi: 10.1002/smll.202200302. Epub 2022 Apr 5. PMID: 35384294. (Pubmed)
     
  • Herwerth M, Kenet S, Schifferer M, Winkler A, Weber M, Snaidero N, Wang M, Lohrberg M, Bennett JL, Stadelmann C, Hemmer B, Misgeld T. A new form of axonal pathology in a spinal model of neuromyelitis optica. Brain. 2022 Jun 3;145(5):1726-1742. doi: 10.1093/brain/awac079. PMID: 35202467; PMCID: PMC9166560. (Pubmed)
     
  • Bader JM, Deigendesch N, Misch M, Mann M, Koch A, Meissner F. Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status. Cell Rep Med. 2023 Jan 17;4(1):100877. doi: 10.1016/j.xcrm.2022.100877. Epub 2022 Dec 29. PMID: 36584682; PMCID: PMC9873829. (Pubmed)
     
  • Bauer A, Puglisi M, Nagl D, Schick JA, Werner T, Klingl A, El Andari J, Hornung V, Kessler H, Götz M, Grimm D, Brack-Werner R. Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1. Adv Sci (Weinh). 2022 May;9(16):e2104979. doi: 10.1002/advs.202104979. Epub 2022 Apr 10. PMID: 35398994; PMCID: PMC9165502. (Pubmed)
     
  • Van Steenbergen V, Burattini L, Trumpp M, Fourneau J, Aljović A, Chahin M, Oh H, D'Ambra M, Bareyre FM. Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury. J Exp Med. 2023 Mar 6;220(3):e20220615. doi: 10.1084/jem.20220615. Epub 2022 Dec 26. PMID: 36571760; PMCID: PMC9794600. (Pubmed)
     
  • Sie C, Kant R, Peter C, Muschaweckh A, Pfaller M, Nirschl L, Moreno HD, Chadimová T, Lepennetier G, Kuhlmann T, Öllinger R, Engleitner T, Rad R, Korn T. IL-24 intrinsically regulates Th17 cell pathogenicity in mice. J Exp Med. 2022 Aug 1;219(8):e20212443. doi: 10.1084/jem.20212443. Epub 2022 Jul 12. PMID: 35819408; PMCID: PMC9280194. (Pubmed)
     
  • Meschkat M, Steyer AM, Weil MT, Kusch K, Jahn O, Piepkorn L, Agüi-Gonzalez P, Phan NTN, Ruhwedel T, Sadowski B, Rizzoli SO, Werner HB, Ehrenreich H, Nave KA, Möbius W. White matter integrity in mice requires continuous myelin synthesis at the inner tongue. Nat Commun. 2022 Mar 4;13(1):1163. doi: 10.1038/s41467-022-28720-y. PMID: 35246535; PMCID: PMC8897471. (Pubmed)
     
  • Lutz K, Musumeci A, Sie C, Dursun E, Winheim E, Bagnoli J, Ziegenhain C, Rausch L, Bergen V, Luecken MD, Oostendorp RAJ, Schraml BU, Theis FJ, Enard W, Korn T, Krug AB. Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage. Nat Commun. 2022 Jun 16;13(1):3456. doi: 10.1038/s41467-022-31054-4. PMID: 35705536; PMCID: PMC9200809. (Pubmed)
     
  • Empl L, Chovsepian A, Chahin M, Kan WYV, Fourneau J, Van Steenbergen V, Weidinger S, Marcantoni M, Ghanem A, Bradley P, Conzelmann KK, Cai R, Ghasemigharagoz A, Ertürk A, Wagner I, Kreutzfeldt M, Merkler D, Liebscher S, Bareyre FM. Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury. Nat Commun. 2022 May 12;13(1):2659. doi: 10.1038/s41467-022-29992-0. PMID: 35551446; PMCID: PMC9098892. (Pubmed)
     
  • Franklin RJM, Simons M. CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities. Neuron. 2022 Nov 2;110(21):3549-3565. doi: 10.1016/j.neuron.2022.09.023. Epub 2022 Oct 12. PMID: 36228613. (Pubmed)
     
  • Liesche-Starnecker F, Schifferer M, Schlegel J, Vollmuth Y, Rubbenstroth D, Delbridge C, Gempt J, Lorenzl S, Schnurbus L, Misgeld T, Rosati M, Beer M, Matiasek K, Wunderlich S, Finck T. Hemorrhagic lesion with detection of infected endothelial cells in human bornavirus encephalitis. Acta Neuropathol. 2022 Aug;144(2):377-379. doi: 10.1007/s00401-022-02442-3. Epub 2022 Jun 3. PMID: 35657496; PMCID: PMC9164175. (Pubmed)
     
  • Daguano Gastaldi V, Bh Wilke J, Weidinger CA, Walter C, Barnkothe N, Teegen B, Luessi F, Stöcker W, Lühder F, Begemann M, Zipp F, Nave KA, Ehrenreich H. Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects. Brain Behav Immun. 2023 Feb;108:135-147. doi: 10.1016/j.bbi.2022.10.016. Epub 2022 Oct 30. PMID: 36323361. (Pubmed)
     
  • Teller J, Jung C, Wilke JBH, Schimmelpfennig SD, Hindermann M, Hinken L, Gabriel MM, Fegbeutel C, Schäfer A, Laser H, Lichtinghagen R, Worthmann H, Weissenborn K, Ehrenreich H. Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia. Brain Behav Immun Health. 2022 Aug 4;24:100494. doi: 10.1016/j.bbih.2022.100494. PMID: 35965838; PMCID: PMC9372600. (Pubmed)
     
  • Vincenti I, Page N, Steinbach K, Yermanos A, Lemeille S, Nunez N, Kreutzfeldt M, Klimek B, Di Liberto G, Egervari K, Piccinno M, Shammas G, Mariotte A, Fonta N, Liaudet N, Shlesinger D, Liuzzi AR, Wagner I, Saadi C, Stadelmann C, Reddy S, Becher B, Merkler D. Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS. Sci Transl Med. 2022 Apr 13;14(640):eabl6058. doi: 10.1126/scitranslmed.abl6058. Epub 2022 Apr 13. PMID: 35417190. (Pubmed)
     
  • Kaya T, Mattugini N, Liu L, Ji H, Cantuti-Castelvetri L, Wu J, Schifferer M, Groh J, Martini R, Besson-Girard S, Kaji S, Liesz A, Gokce O, Simons M. CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci. 2022 Nov;25(11):1446-1457. doi: 10.1038/s41593-022-01183-6. Epub 2022 Oct 24. PMID: 36280798; PMCID: PMC9630119. (Pubmed)
     
  • Merlini A, Haberl M, Strauß J, Hildebrand L, Genc N, Franz J, Chilov D, Alitalo K, Flügel-Koch C, Stadelmann C, Flügel A, Odoardi F. Distinct roles of the meningeal layers in CNS autoimmunity. Nat Neurosci. 2022 Jul;25(7):887-899. doi: 10.1038/s41593-022-01108-3. Epub 2022 Jun 30. PMID: 35773544. (Pubmed)
     
  • Xiao Y, Petrucco L, Hoodless LJ, Portugues R, Czopka T. Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling. Nat Neurosci. 2022 Mar;25(3):280-284. doi: 10.1038/s41593-022-01023-7. Epub 2022 Mar 3. PMID: 35241802; PMCID: PMC8904260. (Pubmed)
     
  • Zambusi A, Novoselc KT, Hutten S, Kalpazidou S, Koupourtidou C, Schieweck R, Aschenbroich S, Silva L, Yazgili AS, van Bebber F, Schmid B, Möller G, Tritscher C, Stigloher C, Delbridge C, Sirko S, Günes ZI, Liebscher S, Schlegel J, Aliee H, Theis F, Meiners S, Kiebler M, Dormann D, Ninkovic J. TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury. Nat Neurosci. 2022 Dec;25(12):1608-1625. doi: 10.1038/s41593-022-01199-y. Epub 2022 Nov 24. PMID: 36424432. (Pubmed)
     
  • Korn T. CNS Treg cells have alternative functions but run on conventional fuel. Nat Immunol. 2022 Jun;23(6):818-819. doi: 10.1038/s41590-022-01201-6. PMID: 35618830. (Pubmed)
     
  • Haimon Z, Frumer GR, Kim JS, Trzebanski S, Haffner-Krausz R, Ben-Dor S, Porat Z, Muschaweckh A, Chappell-Maor L, Boura-Halfon S, Korn T, Jung S. Cognate microglia-T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology. Nat Immunol. 2022 Dec;23(12):1749-1762. doi: 10.1038/s41590-022-01360-6. Epub 2022 Dec 1. PMID: 36456736. (Pubmed)
     
  • Ostersehlt LM, Jans DC, Wittek A, Keller-Findeisen J, Inamdar K, Sahl SJ, Hell SW, Jakobs S. DNA-PAINT MINFLUX nanoscopy. Nat Methods. 2022 Sep;19(9):1072-1075. doi: 10.1038/s41592-022-01577-1. Epub 2022 Sep 1. PMID: 36050490; PMCID: PMC9467913. (Pubmed)
     
  • Hosang L, Canals RC, van der Flier FJ, Hollensteiner J, Daniel R, Flügel A, Odoardi F. The lung microbiome regulates brain autoimmunity. Nature. 2022 Mar;603(7899):138-144. doi: 10.1038/s41586-022-04427-4. Epub 2022 Feb 23. PMID: 35197636. (Pubmed)
     
  • Petridou E, Godinho L. Cellular and Molecular Determinants of Retinal Cell Fate. Annu Rev Vis Sci. 2022 Sep 15;8:79-99. doi: 10.1146/annurev-vision-100820-103154. PMID: 36108104. (Pubmed)
     
  • Galbusera R, Bahn E, Weigel M, Schaedelin S, Franz J, Lu PJ, Barakovic M, Melie-Garcia L, Dechent P, Lutti A, Sati P, Reich DS, Nair G, Brück W, Kappos L, Stadelmann C, Granziera C. Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis. Brain Pathol. 2022 Dec 8:e13136. doi: 10.1111/bpa.13136. Epub ahead of print. PMID: 36480267. (Pubmed)
     
  • Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A. Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice. Cardiovasc Res. 2022 Nov 10;118(14):2932-2945. doi: 10.1093/cvr/cvab359. PMID: 34897380. (Pubmed)
     
  • Sanchez-Gonzalez R, Koupourtidou C, Lepko T, Zambusi A, Novoselc KT, Durovic T, Aschenbroich S, Schwarz V, Breunig CT, Straka H, Huttner HB, Irmler M, Beckers J, Wurst W, Zwergal A, Schauer T, Straub T, Czopka T, Trümbach D, Götz M, Stricker SH, Ninkovic J. Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain. Cells. 2022 Feb 2;11(3):520. doi: 10.3390/cells11030520. PMID: 35159329; PMCID: PMC8834209. (Pubmed)
     
  • Liebich A, Schmid N, Koupourtidou C, Herrmann C, Dietrich KG, Welter H, Ninkovic J, Mayerhofer A. The Molecular Signature of Human Testicular Peritubular Cells Revealed by Single-Cell Analysis. Cells. 2022 Nov 19;11(22):3685. doi: 10.3390/cells11223685. PMID: 36429113; PMCID: PMC9688777. (Pubmed)
     
  • Aljovic A, Zhao S, Chahin M, de la Rosa C, Van Steenbergen V, Kerschensteiner M, Bareyre FM. A deep learning-based toolbox for Automated Limb Motion Analysis (ALMA) in murine models of neurological disorders. Commun Biol. 2022 Feb 15;5(1):131. doi: 10.1038/s42003-022-03077-6. PMID: 35169263; PMCID: PMC8847458. (Pubmed)
     
  • Benakis C, Simats A, Tritschler S, Heindl S, Besson-Girard S, Llovera G, Pinkham K, Kolz A, Ricci A, Theis FJ, Bittner S, Gökce Ö, Peters A, Liesz A. T cells modulate the microglial response to brain ischemia. Elife. 2022 Dec 13;11:e82031. doi: 10.7554/eLife.82031. PMID: 36512388; PMCID: PMC9747154. (Pubmed)
  • Arinrad S, Depp C, Siems SB, Sasmita AO, Eichel MA, Ronnenberg A, Hammerschmidt K, Lüders KA, Werner HB, Ehrenreich H, Nave KA. Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity. Elife. 2023 Mar 9;12:e70792. doi: 10.7554/eLife.70792. PMID: 36892455; PMCID: PMC9998085. (Pubmed)
     
  • Heo D, Ling JP, Molina-Castro GC, Langseth AJ, Waisman A, Nave KA, Möbius W, Wong PC, Bergles DE. Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43. Elife. 2022 Mar 21;11:e75230. doi: 10.7554/eLife.75230. PMID: 35311646; PMCID: PMC8970587. (Pubmed)
     
  • Stejerean-Todoran I, Zimmermann K, Gibhardt CS, Vultur A, Ickes C, Shannan B, Bonilla Del Rio Z, Wölling A, Cappello S, Sung HM, Shumanska M, Zhang X, Nanadikar M, Latif MU, Wittek A, Lange F, Waters A, Brafford P, Wilting J, Urlaub H, Katschinski DM, Rehling P, Lenz C, Jakobs S, Ellenrieder V, Roesch A, Schön MP, Herlyn M, Stanisz H, Bogeski I. MCU controls melanoma progression through a redox-controlled phenotype switch. EMBO Rep. 2022 Nov 7;23(11):e54746. doi: 10.15252/embr.202254746. Epub 2022 Sep 26. PMID: 36156348; PMCID: PMC9638851. (Pubmed)
     
  • Noll C, Hiltensperger M, Aly L, Wicklein R, Afzali AM, Mardin C, Gasperi C, Berthele A, Hemmer B, Korn T, Knier B. Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis. Front Immunol. 2022 Nov 11;13:997043. doi: 10.3389/fimmu.2022.997043. PMID: 36439131; PMCID: PMC9695398. (Pubmed)
     
  • Linnerbauer M, Lößlein L, Farrenkopf D, Vandrey O, Tsaktanis T, Naumann U, Rothhammer V. Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation. Front Immunol. 2022 Jan 3;12:800128. doi: 10.3389/fimmu.2021.800128. PMID: 35046956; PMCID: PMC8762329. (Pubmed)
     
  • Arends M, Weber M, Papan C, Damm M, Surma MA, Spiegel C, Djannatian M, Li S, Connell L, Johannes L, Schifferer M, Klose C, Simons M. Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry. iScience. 2022 Oct 10;25(11):105323. doi: 10.1016/j.isci.2022.105323. PMID: 36310581; PMCID: PMC9615322. (Pubmed)
     
  • Linnerbauer M, Lößlein L, Vandrey O, Tsaktanis T, Beer A, Naumann UJ, Panier F, Beyer T, Nirschl L, Kuramatsu JB, Winkler J, Quintana FJ, Rothhammer V. Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation. JCI Insight. 2022 Apr 8;7(7):e154824. doi: 10.1172/jci.insight.154824. PMID: 35393953; PMCID: PMC9057609. (Pubmed)
     
  • Maisam Afzali A, Stüve L, Pfaller M, Aly L, Steiger K, Knier B, Korn T. Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation. J Mol Med (Berl). 2022 Jun;100(6):933-946. doi: 10.1007/s00109-022-02202-6. Epub 2022 May 10. PMID: 35536323; PMCID: PMC9166880. (Pubmed)
     
  • Benkhoucha M, Tran NL, Breville G, Senoner I, Bradfield PF, Papayannopoulou T, Merkler D, Korn T, Lalive PH. CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation. J Neuroinflammation. 2022 Apr 29;19(1):103. doi: 10.1186/s12974-022-02461-7. PMID: 35488271; PMCID: PMC9052663. (Pubmed)
     
  • Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I. Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. Life Sci Alliance. 2021 Dec 21;5(3):e202101185. doi: 10.26508/lsa.202101185. PMID: 34933920; PMCID: PMC8711852. (Pubmed)
     
  • Aly L, Strauß EM, Feucht N, Weiß I, Berthele A, Mitsdoerffer M, Haass C, Hemmer B, Maier M, Korn T, Knier B. Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders. Mult Scler. 2022 Apr;28(4):522-531. doi: 10.1177/13524585211028831. Epub 2021 Jul 14. PMID: 34259579; PMCID: PMC8961243. (Pubmed)
     
  • Chovsepian A, Empl L, Bareyre FM. Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury. Neural Regen Res. 2023 Jun;18(6):1257-1258. doi: 10.4103/1673-5374.360167. PMID: 36453402; PMCID: PMC9838154. (Pubmed)
     
  • Kalluri SR, Srivastava R, Kenet S, Tanti GK, Dornmair K, Bennett JL, Misgeld T, Hemmer B, Wyss MT, Herwerth M. P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica : P2R Inhibitors Prevent Autoantibody Injury. Neurotherapeutics. 2022 Sep;19(5):1603-1616. doi: 10.1007/s13311-022-01269-w. Epub 2022 Jul 12. PMID: 35821382; PMCID: PMC9606199. (Pubmed)
     
  • Bosch-Queralt M, Tiwari V, Damkou A, Vaculčiaková L, Alexopoulos I, Simons M. A fluorescence microscopy-based protocol for volumetric measurement of lysolecithin lesion-associated de- and re-myelination in mouse brain. STAR Protoc. 2022 Jan 29;3(1):101141. doi: 10.1016/j.xpro.2022.101141. PMID: 35141565; PMCID: PMC8810560. (Pubmed)
     
  • Wang M, Misgeld T, Brill MS. Neural labeling and manipulation by neonatal intraventricular viral injection in mice. STAR Protoc. 2022 Jan 10;3(1):101081. doi: 10.1016/j.xpro.2021.101081. PMID: 35059654; PMCID: PMC8760487. (Pubmed)

2021

  • Wang M, Kleele T, Xiao Y, Plucinska G, Avramopoulos P, Engelhardt S, Schwab MH, Kneussel M, Czopka T, Sherman DL, Brophy PJ, Misgeld T, Brill MS. Completion of neuronal remodeling prompts myelination along developing motor axon branches. J Cell Biol. 2021 Apr 5;220(4):e201911114. doi: 10.1083/jcb.201911114. PMID: 33538762; PMCID: PMC7868780. (Pubmed)
     
  • Frauenstein A, Ebner S, Hansen FM, Sinha A, Phulphagar K, Swatek K, Hornburg D, Mann M, Meissner F. Identification of covalent modifications regulating immune signaling complex composition and phenotype. Mol Syst Biol. 2021 Jul;17(7):e10125. doi: 10.15252/msb.202010125. PMID: 34318608; PMCID: PMC8447602. (Pubmed)
     
  • Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V. The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021 Jul 23;8(5):e1043. doi: 10.1212/NXI.0000000000001043. PMID: 34301821; PMCID: PMC8312279. (Pubmed)
     
  • Eckermann M, Schmitzer B, van der Meer F, Franz J, Hansen O, Stadelmann C, Salditt T. Three-dimensional virtual histology of the human hippocampus based on phase-contrast computed tomography. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2113835118. doi: 10.1073/pnas.2113835118. PMID: 34819378; PMCID: PMC8640721. (Pubmed)
     
  • Wilke JBH, Hindermann M, Berghoff SA, Zihsler S, Arinrad S, Ronnenberg A, Barnkothe N, Steixner-Kumar AA, Röglin S, Stöcker W, Hollmann M, Nave KA, Lühder F, Ehrenreich H. Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis. Mol Psychiatry. 2021 Dec;26(12):7746-7759. doi: 10.1038/s41380-021-01238-3. Epub 2021 Jul 30. PMID: 34331009; PMCID: PMC8872987. (Pubmed)
     
  • Butt UJ, Steixner-Kumar AA, Depp C, Sun T, Hassouna I, Wüstefeld L, Arinrad S, Zillmann MR, Schopf N, Fernandez Garcia-Agudo L, Mohrmann L, Bode U, Ronnenberg A, Hindermann M, Goebbels S, Bonn S, Katschinski DM, Miskowiak KW, Nave KA, Ehrenreich H. Hippocampal neurons respond to brain activity with functional hypoxia. Mol Psychiatry. 2021 Jun;26(6):1790-1807. doi: 10.1038/s41380-020-00988-w. Epub 2021 Feb 9. PMID: 33564132; PMCID: PMC8440186. (Pubmed)
     
  • Mitsdoerffer M, Di Liberto G, Dötsch S, Sie C, Wagner I, Pfaller M, Kreutzfeldt M, Fräßle S, Aly L, Knier B, Busch DH, Merkler D, Korn T. Formation and immunomodulatory function of meningeal B cell aggregates in progressive CNS autoimmunity. Brain. 2021 Jul 28;144(6):1697-1710. doi: 10.1093/brain/awab093. Erratum in: Brain. 2021 Jul 14;: PMID: 33693558. (Pubmed)
     
  • Mahler C, Schumacher AM, Unterrainer M, Kaiser L, Höllbacher T, Lindner S, Havla J, Ertl-Wagner B, Patzig M, Seelos K, Neitzel J, Mäurer M, Krumbholz M, Metz I, Brück W, Stadelmann C, Merkler D, Gass A, Milenkovic V, Bartenstein P, Albert NL, Kümpfel T, Kerschensteiner M. TSPO PET imaging of natalizumab-associated progressive multifocal leukoencephalopathy. Brain. 2021 Oct 22;144(9):2683-2695. doi: 10.1093/brain/awab127. PMID: 33757118. (Pubmed)
     
  • Gouna G, Klose C, Bosch-Queralt M, Liu L, Gokce O, Schifferer M, Cantuti-Castelvetri L, Simons M. TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination. J Exp Med. 2021 Oct 4;218(10):e20210227. doi: 10.1084/jem.20210227. Epub 2021 Aug 23. PMID: 34424266; PMCID: PMC8404472. (Pubmed)
     
  • Heindl S, Ricci A, Carofiglio O, Zhou Q, Arzberger T, Lenart N, Franzmeier N, Hortobagyi T, Nelson PT, Stowe AM, Denes A, Edbauer D, Liesz A. Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. J Exp Med. 2021 Aug 2;218(8):e20202411. doi: 10.1084/jem.20202411. Epub 2021 May 26. PMID: 34037669; PMCID: PMC8160576. (Pubmed)
     
  • Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer A, Stadelmann C, Nessler S, Gärtner J. Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nat Commun. 2021 Nov 11;12(1):6530. doi: 10.1038/s41467-021-26880-x. PMID: 34764281; PMCID: PMC8586222. (Pubmed)
     
  • Konen T, Stumpf D, Grotjohann T, Jansen I, Bossi M, Weber M, Jensen N, Hell SW, Jakobs S. The Positive Switching Fluorescent Protein Padron2 Enables Live-Cell Reversible Saturable Optical Linear Fluorescence Transitions (RESOLFT) Nanoscopy without Sequential Illumination Steps. ACS Nano. 2021 Jun 22;15(6):9509-9521. doi: 10.1021/acsnano.0c08207. Epub 2021 May 21. PMID: 34019380; PMCID: PMC8291764. (Pubmed)
     
  • Safaiyan S, Besson-Girard S, Kaya T, Cantuti-Castelvetri L, Liu L, Ji H, Schifferer M, Gouna G, Usifo F, Kannaiyan N, Fitzner D, Xiang X, Rossner MJ, Brendel M, Gokce O, Simons M. White matter aging drives microglial diversity. Neuron. 2021 Apr 7;109(7):1100-1117.e10. doi: 10.1016/j.neuron.2021.01.027. Epub 2021 Feb 18. PMID: 33606969. (Pubmed)
     
  • Bocchi R, Masserdotti G, Götz M. Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches. Neuron. 2022 Feb 2;110(3):366-393. doi: 10.1016/j.neuron.2021.11.023. Epub 2021 Dec 18. PMID: 34921778. (Pubmed)
     
  • Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C, Simons M. Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nat Metab. 2021 Feb;3(2):211-227. doi: 10.1038/s42255-021-00341-7. Epub 2021 Feb 18. Erratum in: Nat Metab. 2023 Mar;5(3):531. PMID: 33619376; PMCID: PMC7610359. (Pubmed)
     
  • Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G. Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nat Neurosci. 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. PMID: 33349711; PMCID: PMC7116742. (Pubmed)
     
  • Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M. Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. Nat Neurosci. 2021 Mar;24(3):355-37. doi: 10.1038/s41593-020-00780-7. Epub 2021 Jan 25. PMID: 33495636. (Pubmed)
     
  • Meinhardt J, Radke J, Dittmayer C, Franz J, Thomas C, Mothes R, Laue M, Schneider J, Brünink S, Greuel S, Lehmann M, Hassan O, Aschman T, Schumann E, Chua RL, Conrad C, Eils R, Stenzel W, Windgassen M, Rößler L, Goebel HH, Gelderblom HR, Martin H, Nitsche A, Schulz-Schaeffer WJ, Hakroush S, Winkler MS, Tampe B, Scheibe F, Körtvélyessy P, Reinhold D, Siegmund B, Kühl AA, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, Ingold-Heppner B, Stadelmann C, Drosten C, Corman VM, Radbruch H, Heppner FL. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci. 2021 Feb;24(2):168-175. doi: 10.1038/s41593-020-00758-5. Epub 2020 Nov 30. PMID: 33257876. (Pubmed)
     
  • Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. PMID: 34675436; PMCID: PMC8553622. (Pubmed)
     
  • Hiltensperger M, Beltrán E, Kant R, Tyystjärvi S, Lepennetier G, Domínguez Moreno H, Bauer IJ, Grassmann S, Jarosch S, Schober K, Buchholz VR, Kenet S, Gasperi C, Öllinger R, Rad R, Muschaweckh A, Sie C, Aly L, Knier B, Garg G, Afzali AM, Gerdes LA, Kümpfel T, Franzenburg S, Kawakami N, Hemmer B, Busch DH, Misgeld T, Dornmair K, Korn T. Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. Nat Immunol. 2021 Jul;22(7):880-892. doi: 10.1038/s41590-021-00948-8. Epub 2021 Jun 7. PMID: 34099917; PMCID: PMC7611097. (Pubmed)
     
  • Tuzlak S, Dejean AS, Iannacone M, Quintana FJ, Waisman A, Ginhoux F, Korn T, Becher B. Repositioning TH cell polarization from single cytokines to complex help. Nat Immunol. 2021 Oct;22(10):1210-1217. doi: 10.1038/s41590-021-01009-w. Epub 2021 Sep 20. PMID: 34545250. (Pubmed)
     
  • Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A. Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity. 2021 Apr 13;54(4):648-659.e8. doi: 10.1016/j.immuni.2021.02.004. Epub 2021 Mar 4. PMID: 33667383. (Pubmed)
     
  • Löhndorf A, Hosang L, Dohle W, Odoardi F, Waschkowski SA, Rosche A, Bauche A, Winzer R, Tolosa E, Windhorst S, Marry S, Flügel A, Potter BVL, Diercks BP, Guse AH. 2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: Identification of a new and potent inhibitor. Biochim Biophys Acta Mol Cell Res. 2021 May;1868(6):118988. doi: 10.1016/j.bbamcr.2021.118988. Epub 2021 Feb 10. PMID: 33581218; PMCID: PMC8062851. (Pubmed)
     
  • Fernandez Garcia-Agudo L, Steixner-Kumar AA, Curto Y, Barnkothe N, Hassouna I, Jähne S, Butt UJ, Grewe K, Weber MS, Green K, Rizzoli S, Nacher J, Nave KA, Ehrenreich H. Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Cell Rep. 2021 Aug 24;36(8):109548. doi: 10.1016/j.celrep.2021.109548. PMID: 34433021. (Pubmed)
     
  • Penkert H, Bertrand A, Tiwari V, Breimann S, Müller SA, Jordan PM, Gerl MJ, Klose C, Cantuti-Castelvetri L, Bosch-Queralt M, Levental I, Lichtenthaler SF, Werz O, Simons M. Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery. Cell Rep. 2021 Oct 26;37(4):109898. doi: 10.1016/j.celrep.2021.109898. PMID: 34706241; PMCID: PMC8567315. (Pubmed)
     
  • Kempf J, Knelles K, Hersbach BA, Petrik D, Riedemann T, Bednarova V, Janjic A, Simon-Ebert T, Enard W, Smialowski P, Götz M, Masserdotti G. Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2. Cell Rep. 2021 Jul 20;36(3):109409. doi: 10.1016/j.celrep.2021.109409. Erratum in: Cell Rep. 2021 Aug 17;36(7):109571. PMID: 34289357; PMCID: PMC8316252. (Pubmed)
     
  • Phulphagar K, Kühn LI, Ebner S, Frauenstein A, Swietlik JJ, Rieckmann J, Meissner F. Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis. Cell Rep. 2021 Mar 9;34(10):108826. doi: 10.1016/j.celrep.2021.108826. PMID: 33691121. (Pubmed)
     
  • Brüser C, Keller-Findeisen J, Jakobs S. The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels. Cell Rep. 2021 Nov 23;37(8):110000. doi: 10.1016/j.celrep.2021.110000. PMID: 34818548. (Pubmed)
     
  • Loy K, Fourneau J, Meng N, Denecke C, Locatelli G, Bareyre FM. Semaphorin 7A restricts serotonergic innervation and ensures recovery after spinal cord injury. Cell Mol Life Sci. 2021 Mar;78(6):2911-2927. doi: 10.1007/s00018-020-03682-w. Epub 2020 Oct 30. PMID: 33128105; PMCID: PMC8004489. (Pubmed)
     
  • Engerer P, Petridou E, Williams PR, Suzuki SC, Yoshimatsu T, Portugues R, Misgeld T, Godinho L. Notch-mediated re-specification of neuronal identity during central nervous system development. Curr Biol. 2021 Nov 8;31(21):4870-4878.e5. doi: 10.1016/j.cub.2021.08.049. Epub 2021 Sep 16. PMID: 34534440. (Pubmed)
     
  • Götz M, Bocchi R. Neuronal replacement: Concepts, achievements, and call for caution. Curr Opin Neurobiol. 2021 Aug;69:185-192. doi: 10.1016/j.conb.2021.03.014. Epub 2021 May 10. PMID: 33984604; PMCID: PMC8411662. (Pubmed)
     
  • Korn T, Hiltensperger M. Role of IL-6 in the commitment of T cell subsets. Cytokine. 2021 Oct;146:155654. doi: 10.1016/j.cyto.2021.155654. Epub 2021 Jul 26. PMID: 34325116; PMCID: PMC8375581. (Pubmed)
     
  • Van Steenbergen V, Bareyre FM. Chemogenetic approaches to unravel circuit wiring and related behavior after spinal cord injury. Exp Neurol. 2021 Nov;345:113839. doi: 10.1016/j.expneurol.2021.113839. Epub 2021 Aug 10. PMID: 34389362. (Pubmed)
     
  • Eira J, Magalhães J, Macedo N, Pero ME, Misgeld T, Sousa MM, Bartolini F, Liz MA. Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation. Front Cell Dev Biol. 2021 Nov 8;9:747699. doi: 10.3389/fcell.2021.747699. PMID: 34820375; PMCID: PMC8606651. (Pubmed)
     
  • Senís E, Esgleas M, Najas S, Jiménez-Sábado V, Bertani C, Giménez-Alejandre M, Escriche A, Ruiz-Orera J, Hergueta-Redondo M, Jiménez M, Giralt A, Nuciforo P, Albà MM, Peinado H, Del Toro D, Hove-Madsen L, Götz M, Abad M. TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Front Cell Dev Biol. 2021 Dec 31;9:747667. doi: 10.3389/fcell.2021.747667. PMID: 35036403; PMCID: PMC8758570. (Pubmed)
     
  • Tampe D, Hakroush S, Bösherz MS, Franz J, Hofmann-Winkler H, Pöhlmann S, Kluge S, Moerer O, Stadelmann C, Ströbel P, Winkler MS, Tampe B. Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study. Front Med (Lausanne). 2021 May 25;8:644715. doi: 10.3389/fmed.2021.644715. PMID: 34113632; PMCID: PMC8185060. (Pubmed)
     
  • Schifferer M, Snaidero N, Djannatian M, Kerschensteiner M, Misgeld T. Niwaki Instead of Random Forests: Targeted Serial Sectioning Scanning Electron Microscopy With Reimaging Capabilities for Exploring Central Nervous System Cell Biology and Pathology. Front Neuroanat. 2021 Oct 13;15:732506. doi: 10.3389/fnana.2021.732506. PMID: 34720890; PMCID: PMC8548362. (Pubmed)
     
  • Bergner CG, Genc N, Hametner S, Franz J, van der Meer F, Mitkovski M, Weber MS, Stoltenburg-Didinger G, Kühl JS, Köhler W, Brück W, Gärtner J, Stadelmann C. Concurrent axon and myelin destruction differentiates X-linked adrenoleukodystrophy from multiple sclerosis. Glia. 2021 Oct;69(10):2362-2377. doi: 10.1002/glia.24042. Epub 2021 Jun 17. PMID: 34137074. (Pubmed)
     
  • Butt UJ, Hassouna I, Fernandez Garcia-Agudo L, Steixner-Kumar AA, Depp C, Barnkothe N, Zillmann MR, Ronnenberg A, Bonet V, Goebbels S, Nave KA, Ehrenreich H. CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge. Int J Mol Sci. 2021 Mar 20;22(6):3164. doi: 10.3390/ijms22063164. PMID: 33804598; PMCID: PMC8003772. (Pubmed)
     
  • Günther C, Rothhammer V, Karow M, Neurath M, Winner B. The Gut-Brain Axis in Inflammatory Bowel Disease-Current and Future Perspectives. Int J Mol Sci. 2021 Aug 18;22(16):8870. doi: 10.3390/ijms22168870. PMID: 34445575; PMCID: PMC8396333. (Pubmed)
     
  • Edgar JM, McGowan E, Chapple KJ, Möbius W, Lemgruber L, Insall RH, Nave KA, Boullerne A. Río-Hortega's drawings revisited with fluorescent protein defines a cytoplasm-filled channel system of CNS myelin. J Anat. 2021 Dec;239(6):1241-1255. doi: 10.1111/joa.13577. Epub 2021 Oct 28. PMID: 34713444; PMCID: PMC8602028. (Pubmed)
     
  • Kettwig M, Klemp H, Nessler S, Streit F, Krätzner R, Rosewich H, Gärtner J. Targeted metabolomics revealed changes in phospholipids during the development of neuroinflammation in Abcd1tm1Kds mice and X-linked adrenoleukodystrophy patients. J Inherit Metab Dis. 2021 Sep;44(5):1174-1185. doi: 10.1002/jimd.12389. Epub 2021 May 5. PMID: 33855724. (Pubmed)
     
  • Klemp HG, Kettwig M, Streit F, Gärtner J, Rosewich H, Krätzner R. LC-MS Based Platform Simplifies Access to Metabolomics for Peroxisomal Disorders. Metabolites. 2021 May 29;11(6):347. doi: 10.3390/metabo11060347. PMID: 34072483; PMCID: PMC8226985. (Pubmed)
     
  • Begemann M, Gross O, Wincewicz D, Hardeland R, Daguano Gastaldi V, Vieta E, Weissenborn K, Miskowiak KW, Moerer O, Ehrenreich H. Addressing the 'hypoxia paradox' in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues. Mol Med. 2021 Sep 26;27(1):120. doi: 10.1186/s10020-021-00381-5. PMID: 34565332; PMCID: PMC8474703. (Pubmed)
     
  • Fourneau J, Bareyre FM. Semaphorin7A: its role in the control of serotonergic circuits and functional recovery following spinal cord injury. Neural Regen Res. 2022 May;17(5):959-962. doi: 10.4103/1673-5374.324828. PMID: 34558508; PMCID: PMC8552865. (Pubmed)
     
  • Liu L, Besson-Girard S, Ji H, Gehring K, Bulut B, Kaya T, Usifo F, Simons M, Gokce O. Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing. STAR Protoc. 2021 Jun 10;2(2):100590. doi: 10.1016/j.xpro.2021.100590. PMID: 34159323; PMCID: PMC8196224. (Pubmed)
     
  • Zhu J, Cao J, Liesz A, Roth S. A macrophage-T cell coculture model for severe tissue injury-induced T cell death. STAR Protoc. 2021 Dec 1;2(4):100983. doi: 10.1016/j.xpro.2021.100983. PMID: 34927092; PMCID: PMC8646263. (Pubmed)
     
  • Zhang Y, Liesz A, Li P. Coming to the Rescue: Regulatory T Cells for Promoting Recovery After Ischemic Stroke. Stroke. 2021 Dec;52(12):e837-e841. doi: 10.1161/STROKEAHA.121.036072. Epub 2021 Nov 22. PMID: 34807742. (Pubmed)
     
  • Winkler A, Wrzos C, Haberl M, Weil MT, Gao M, Möbius W, Odoardi F, Thal DR, Chang M, Opdenakker G, Bennett JL, Nessler S, Stadelmann C. Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration. J Clin Invest. 2021 Mar 1;131(5):e141694. doi: 10.1172/JCI141694. PMID: 33645550; PMCID: PMC7919716. (Pubmed)

2020

  • Penkert H, Lauber C, Gerl MJ, Klose C, Damm M, Fitzner D, Flierl-Hecht A, Kümpfel T, Kerschensteiner M, Hohlfeld R, Gerdes LA, Simons M. Plasma lipidomics of monozygotic twins discordant for multiple sclerosis. Ann Clin Transl Neurol. 2020 Dec;7(12):2461-2466. doi: 10.1002/acn3.51216. Epub 2020 Nov 7. PMID: 33159711; PMCID: PMC7732246. (Pubmed)
     
  • Pan H, Steixner-Kumar AA, Seelbach A, Deutsch N, Ronnenberg A, Tapken D, von Ahsen N, Mitjans M, Worthmann H, Trippe R, Klein-Schmidt C, Schopf N, Rentzsch K, Begemann M, Wienands J, Stöcker W, Weissenborn K, Hollmann M, Nave KA, Lühder F, Ehrenreich H. Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury. Mol Psychiatry. 2021 Jun;26(6):2471-2482. doi: 10.1038/s41380-020-0672-1. Epub 2020 Feb 24. PMID: 32089545; PMCID: PMC8440197. (Pubmed)
     
  • Jäckle K, Zeis T, Schaeren-Wiemers N, Junker A, van der Meer F, Kramann N, Stadelmann C, Brück W. Molecular signature of slowly expanding lesions in progressive multiple sclerosis. Brain. 2020 Jul 1;143(7):2073-2088. doi: 10.1093/brain/awaa158. PMID: 32577755. (Pubmed)
     
  • Gruenenfelder FI, McLaughlin M, Griffiths IR, Garbern J, Thomson G, Kuzman P, Barrie JA, McCulloch ML, Penderis J, Stassart R, Nave KA, Edgar JM. Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease. Brain. 2020 May 1;143(5):1383-1399. doi: 10.1093/brain/awaa080. PMID: 32419025; PMCID: PMC7462093. (Pubmed)
     
  • Cunha MI, Su M, Cantuti-Castelvetri L, Müller SA, Schifferer M, Djannatian M, Alexopoulos I, van der Meer F, Winkler A, van Ham TJ, Schmid B, Lichtenthaler SF, Stadelmann C, Simons M. Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis. J Exp Med. 2020 May 4;217(5):e20191390. doi: 10.1084/jem.20191390. PMID: 32078678; PMCID: PMC7201919. (Pubmed)
     
  • Snaidero N, Schifferer M, Mezydlo A, Zalc B, Kerschensteiner M, Misgeld T. Myelin replacement triggered by single-cell demyelination in mouse cortex. Nat Commun. 2020 Sep 29;11(1):4901. doi: 10.1038/s41467-020-18632-0. PMID: 32994410; PMCID: PMC7525521. (Pubmed)
     
  • LaClair KD, Zhou Q, Michaelsen M, Wefers B, Brill MS, Janjic A, Rathkolb B, Farny D, Cygan M, de Angelis MH, Wurst W, Neumann M, Enard W, Misgeld T, Arzberger T, Edbauer D. Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. Acta Neuropathol. 2020 Aug;140(2):121-142. doi: 10.1007/s00401-020-02176-0. Epub 2020 Jun 19. PMID: 32562018; PMCID: PMC7360660. (Pubmed)
     
  • Wildemann B, Jarius S, Franz J, Ruprecht K, Reindl M, Stadelmann C. MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis. Acta Neuropathol. 2021 Jan;141(1):127-131. doi: 10.1007/s00401-020-02236-5. Epub 2020 Oct 19. PMID: 33078290; PMCID: PMC7785547. (Pubmed)
     
  • Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, Bauer T, Hüser N, Hartmann D, Laschinger M, Eyerich K, Eyerich S, Anton M, Streeter M, Wang T, Schraven B, Spiegel D, Assaad F, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA, Höchst B. Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal. Nat Immunol. 2020 May;21(5):555-566. doi: 10.1038/s41590-020-0666-9. Epub 2020 Apr 23. PMID: 32327756. (Pubmed)
     
  • Mukherjee C, Kling T, Russo B, Miebach K, Kess E, Schifferer M, Pedro LD, Weikert U, Fard MK, Kannaiyan N, Rossner M, Aicher ML, Goebbels S, Nave KA, Krämer-Albers EM, Schneider A, Simons M. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Cell Metab. 2020 Aug 4;32(2):259-272.e10. doi: 10.1016/j.cmet.2020.05.019. Epub 2020 Jun 11. PMID: 32531201; PMCID: PMC7116799. (Pubmed)
     
  • Lubetzki C, Zalc B, Williams A, Stadelmann C, Stankoff B. Remyelination in multiple sclerosis: from basic science to clinical translation. Lancet Neurol. 2020 Aug;19(8):678-688. doi: 10.1016/S1474-4422(20)30140-X. PMID: 32702337. (Pubmed)
     
  • Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20. PMID: 33082293; PMCID: PMC7857391. (Pubmed)
     
  • Lohrberg M, Winkler A, Franz J, van der Meer F, Ruhwedel T, Sirmpilatze N, Dadarwal R, Handwerker R, Esser D, Wiegand K, Hagel C, Gocht A, König FB, Boretius S, Möbius W, Stadelmann C, Barrantes-Freer A. Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination. Acta Neuropathol Commun. 2020 Dec 24;8(1):224. doi: 10.1186/s40478-020-01105-2. PMID: 33357244; PMCID: PMC7761156. (Pubmed)
     
  • Fitzner D, Bader JM, Penkert H, Bergner CG, Su M, Weil MT, Surma MA, Mann M, Klose C, Simons M. Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. Cell Rep. 2020 Sep 15;32(11):108132. doi: 10.1016/j.celrep.2020.108132. PMID: 32937123. (Pubmed)
     
  • Zambusi A, Pelin Burhan Ö, Di Giaimo R, Schmid B, Ninkovic J. Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon. Cells. 2020 Feb 3;9(2):350. doi: 10.3390/cells9020350. PMID: 32028681; PMCID: PMC7072227. (Pubmed)
     
  • Kislinger G, Gnägi H, Kerschensteiner M, Simons M, Misgeld T, Schifferer M. Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution. iScience. 2020 Jul 24;23(7):101290. doi: 10.1016/j.isci.2020.101290. Epub 2020 Jun 20. PMID: 32622266; PMCID: PMC7334410. (Pubmed)
     
  • Granier C, Schwarting J, Fourli E, Laage-Gaupp F, Hennrich AA, Schmalz A, Jacobi A, Wesolowski M, Conzelmann KK, Bareyre FM. Formation of somatosensory detour circuits mediates functional recovery following dorsal column injury. Sci Rep. 2020 Jul 2;10(1):10953. doi: 10.1038/s41598-020-67866-x. PMID: 32616790; PMCID: PMC7331809. (Pubmed)
     
  • Kislinger G, Gnägi H, Kerschensteiner M, Simons M, Misgeld T, Schifferer M. ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex. STAR Protoc. 2020 Dec 16;1(3):100232. doi: 10.1016/j.xpro.2020.100232. PMID: 33377119; PMCID: PMC7757728. (Pubmed)