Project Area A: Immunological Checkpoints of CNS Recovery

A01

CD96 as checkpoint for the persistence of T cell responses in the central nervous system
Korn, Dept. of Experimental Neuroimmunology, TUM Munich

A02

Multicellular interactions of microglia in the chronically inflamed brain after ischemic stroke
Liesz, Institute for Stroke and Dementia Research, LMU Klinikum

A03

Checkpoints determining recovery from acute autoimmune CNS grey matter lesions
Flügel, Institute for Neuroimmunology and Multiple Sclerosis Research, UMG Göttingen

A04

The role of the meninges in the resolution of acute autoimmune CNS lesions
Merlini/Odoardi, Institute for Neuroimmunology and Multiple Sclerosis Research, UMG Göttingen

A06

Linking lipid metabolism to inflammation in models of demyelinating injury
Berghoff/Simons, Institute of Neuronal Cell Biology, TUM Munich

A08

Deciphering the heterogeneity of B-lymphoid subpopulations impacting on CNS recovery from acute multiple sclerosis bouts
Weber/Wienands, Institute of Neuropathology/Institute for Cellular and Molecular Immunology, UMG Göttingen

Project Area B: Glial Checkpoints of CNS Recovery

B01

Function of satellite oligodendrocytes in remyelination
Stadelmann/Simons, Institute of Neuropathology/Institute of Neuronal Cell Biology, UMG Göttingen/TUM Munich

B02

Targeting immunological networks to promote recovery in childhood-onset white matter diseases
Nessler/Gärtner, Institute of Neuropathology/Dept. Pediatrics and Adolescent Medicine, UMG Göttingen

B03

Glia-glia interactions as checkpoints of antibody-mediated CNS lesion formation and resolution
Stadelmann/Misgeld, Institute of Neuropathology/Institute of Neuronal Cell Biology, UMG Göttingen/TUM Munich

B05

Cross-talk between innate immunity and extracellular vesicles (EV) forms a checkpoint regulating long-lasting neuroinflammation after brain injury
Ninkovic, Department of Anatomy and Cell Biology, LMU Munich

B06

Unmasking molecular networks that orchestrate human glial cell responses during CNS injury
Schäfer, Dept. Psychiatry and Psychotherapy, TUM Munich

B07

Molecular checkpoints regulating the repair capacity of surviving oligodendrocytes in an inflammatory environment
Jäkel/Kerschensteiner, Institute for Stroke and Dementia Research/Institute of Clinical Neuroimmunology, LMU Munich

Project Area C: Neuronal Checkpoints of CNS Recovery

C01

EPO/EPOR signalling in the recovery from brain injury and disease
Ehrenreich/Nave, Clinical Neuroscience, MPI-NAT, Göttingen

C02

In vivo detection and targeting of neuroenergetic checkpoints determining neuronal resilience and function during CNS inflammation 
Kerschensteiner/Misgeld , Institute of Clinical Neuroimmunology/Institute of Neuronal Cell Biology, LUM/TUM Munich

C03

Cellular and molecular checkpoints of circuit refinement following traumatic injuries of the CNS
Bareyre, Institute of Clinical Neuroimmunology, LMU Munich

C04

Brain network remodelling as a checkpoint of recovery after acute retinal injury
Godinho/Portugues, Institute of Neuronal Cell Biology, LMU Munich

C05

Glial checkpoints for neuronal circuitry recovery 
Götz, Dept. of Physiological Genomics, LMU Munich

C06

Understanding checkpoints of interneuron sculpting for neuronal remodelling of microcircuits to promote CNS repair 
Wahl, Institute for Stroke and Dementia Research, Institute of Anatomy, LMU Munich

Service Projects

Z01

Bioimaging and Tissue Analysis Platform
Schifferer/Stadelmann/Misgeld, DZNE/Institute of Neuropathology/Institute of Neuronal Cell Biology, Munich/UMG Göttingen/TUM Munich

Z02

Genomics and Bioinformatics Platform
Klughammer/Beißbarth/Simons, Gene Center and Dept. of Biochemistry/Institute of Medical Bioinformatics/Institute of Neuronal Cell Biology, LMU Munich/UMG Göttingen/TUM Munich

Past projects and collaborations

First funding period: 2020 – 2023

Name Project-Number Project-Title University
Ludovico Cantuti-Castelvetri A06 The role of lipid-sensing nuclear receptors as checkpoints in regulating phagocyte function during recovery from demyelinating injury TUM
Felix Meissner A07 Functional proteomics dissection of phagocyte derived signals during CNS inflammation and recovery UK Bonn
Wolfgang Brück B02 Inflammatory neurodegeneration and repair mechanisms in childhood onset autoimmune and neurometabolic demyelinating CNS disease UMG
Veit Rothammer B04 Interaction of glial and CNS infiltrating immune cells in the recovery from acute inflammatory and hypoxic tissue damage in the CNS UK Erlangen
Stefan Jakobs Z01 Bioimaging Platform UMG
Özgün Gökce Z02 Genomics and Bioinformatics Platform LMU